논문검색
Author Ji Yoon Kim, Yeon Sil Kim, Mi Ryung Ryu, Sung Whan Kim, Chul Seung Kay, Sei Chul Yoon, Woo Chan Park, Byung Joo Song, Se Jeong Oh, Sang Seol Jung, Jong Man Won, Seung Nam Kim, Su Mi Chung
Place of duty Departments of Radiation Oncology and Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Title The Effect of Simulation on Recurrence after Breast-Conserving Surgery and Radiotherapy: Preliminary Results
Publicationinfo Cancer Res Treat. 2006 Feb; 038(01): 40-47.
Key_word Breast neoplasms,Radiotherapy,Simulation,Recurrence
Full-Text
Abstract Purpose: To evaluate the effect of the simulation method on recurrence among the patients who received radiotherapy after breast-conserving surgery (BCS) for early breast carcinoma. Methods and Materials: Between 1995 and 2000, 70 patients with stage I-II breast carcinoma underwent breast-conserving surgery and adjuvant radiotherapy. Twenty nine patients (41.4%) were simulated with the 2D contour-based method (September 1995 to August 1997) and 41 patients (58.6%) were simulated with the 3D CT-based method (September 1997 to February 2000). To analyze the effect of the simulation method, the patient and treatment characteristics were compared. Results: The characteristics were similar for the patients between the 2D contour-based simulation group and the 3D CT-based simulation group. During a median follow-up period of 75 months, 4 (13.8%) of 29 patients who were treated with 2D simulation and 1 (2.4%) of 41 patients who were treated with 3D simulation group devel-oped treatment failure. The five-year survival rates were 89.2% and 95.1% between the 2D and 3D simulation groups (p=0.196). The five-year disease free survival (DFS) rates were 86.2% and 97.5% between the 2D and 3D simulation groups (p=0.0636). On univariate analysis, age>40 (p= 0.0226) and the number of dissected axillary lymph node>or=10 (p=0.0435) were independent predictors of improved 5-year DFS. Conclusions: Although our data showed marginal significance for the DFS between the two groups, it is insufficient, due to the small number of patients in our study, to prove whether 3D CT-based simulation might improve the DFS and reduce the risk of recurrence when compared with 2D contour-based simulation. Further study is needed with a larger group of patients. (Cancer Res Treat. 2006;38:40-47)